Positive regulation of interleukin-23 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-23 production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLCG2, CCDC88B, and FMNL1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-23 production activity versus PLCG2 in GBM (Pearson r = 0.80).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLCG2 →	+0.679	+0.151	<.001	<.001	3	10
GBM	CCDC88B →	+0.430	+0.122	<.001	<.001	3	9
GBM	FMNL1 →	+0.656	+0.153	<.001	<.001	3	9
LSCC	RGS14_S288 →	+0.917	+0.093	<.001	<.001	3	9
COAD	RCSD1_S351 →	+0.585	+0.063	<.001	<.001	3	8
BRCA	CYBB →	+0.741	+0.040	<.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032747 vs PLCG2 — GBM

Explore this scatter interactively →