Positive regulation of interleukin-23 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-23 production pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR6775, MIR548G, and TRAV21, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-23 production activity versus MIR6775 in HNSC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR6775 →	+1.031	+0.577	.001	.008	3	3
GBM	MIR548G →	-0.448	-0.455	.002	.002	3	3
UCEC	TRAV21 →	+0.843	+0.971	.001	<.001	3	3
UCEC	LINC01678 →	+0.338	+0.749	<.001	.002	3	3
LUAD	RPSAP76 →	+0.125	+0.532	.002	.003	3	3
BRCA	RPS3AP43 →	+0.292	+1.022	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032747 vs MIR6775 — HNSC

Explore this scatter interactively →