Positive regulation of interleukin-23 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-23 production pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMS1, GABARAPL1, and C10orf88, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PMS1 grouped by Positive regulation of interleukin-23 production-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PMS1 →	+0.482	+0.651	.003	.004	3	4
KIDNEY	GABARAPL1 →	-1.420	-1.381	<.001	<.001	3	4
KIDNEY	C10orf88 →	+0.972	+0.936	.003	.008	3	4
LUNG_SCLC	CLUH →	-0.972	-0.554	<.001	.006	3	3
BONE	C9orf64 →	+3.437	+1.695	<.001	<.001	3	3
URINARY_TRACT	CSTF3 →	+0.868	+1.267	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PMS1 by Positive regulation of interleukin-23 production activity — LARGE_INTESTINE

Explore this box plot interactively →