Positive regulation of interleukin-23 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-23 production pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYD88, OSTF1, and PLCG2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-23 production activity versus MYD88 in OVARY (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MYD88 →	+1.928	+1.095	<.001	<.001	3	15
CNS	OSTF1 →	+1.394	+0.956	<.001	<.001	3	7
BLOOD_Lymphoma	PLCG2 →	+1.972	+0.138	<.001	<.001	3	7
SOFT_TISSUE	MX1 →	+2.053	+0.980	.001	<.001	3	6
BLOOD_Leukemia	UNC93B1 →	+1.552	+0.193	<.001	<.001	3	6
BLOOD_Leukemia	IL17RA →	+1.425	+0.164	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032747 vs MYD88 — OVARY

Explore this scatter interactively →