Positive regulation of interleukin-2 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-2 production pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGAL, RASAL3, and ARHGAP9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-2 production activity versus ITGAL in LSCC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ITGAL →	+0.848	+0.375	<.001	<.001	3	7
LSCC	RASAL3 →	+0.778	+0.332	<.001	<.001	3	6
GBM	ARHGAP9 →	+0.742	+0.615	<.001	.001	3	6
GBM	FAM78A →	+0.709	+0.396	<.001	.002	3	6
HNSC	SPN →	+0.677	+0.297	.002	.003	3	6
LSCC	PSTPIP1 →	+0.590	+0.420	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032743 vs ITGAL — LSCC

Explore this scatter interactively →