Positive regulation of interleukin-2 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-2 production pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELAC2, TOMM7, and LMF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-2 production activity versus ELAC2 in LIVER (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ELAC2 →	+0.851	+0.302	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	TOMM7 →	+1.259	+0.599	.001	.007	3	5
BLOOD_Leukemia	LMF1 →	+0.778	+0.178	<.001	.002	3	5
OVARY	CCT4 →	+0.816	+0.417	.001	.006	3	5
BLOOD_Lymphoma	ZNF697 →	+0.943	+0.241	.004	.002	3	5
BREAST	TTC27 →	+0.665	+0.331	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032743 vs ELAC2 — LIVER

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