Positive regulation of interleukin-18 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-18 production pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and SAMSN1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-18 production activity versus RCSD1 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RCSD1 →	+0.635	+0.133	<.001	<.001	3	10
UCEC	RCSD1_S351 →	+0.649	+0.122	<.001	<.001	3	10
OV	SAMSN1 →	+0.722	+0.138	.001	.001	3	10
BRCA	SAMSN1_S23 →	+0.941	+0.123	<.001	<.001	3	10
OV	SASH3 →	+0.457	+0.145	<.001	<.001	3	10
GBM	SKAP2 →	+0.637	+0.100	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032741 vs RCSD1 — BRCA

Explore this scatter interactively →