Positive regulation of interleukin-18 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-18 production pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDCD1, GBP1, and CCR1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-18 production activity versus PDCD1 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PDCD1 →	+1.240	+0.307	<.001	<.001	3	7
BRCA	GBP1 →	+1.324	+0.237	<.001	<.001	3	7
OV	CCR1 →	+0.973	+0.163	<.001	<.001	3	7
GBM	FCGR1B →	+0.453	+0.165	.007	.005	3	7
UCEC	PLA2G2D →	+1.577	+0.242	<.001	<.001	3	6
BRCA	IRF1 →	+0.981	+0.253	<.001	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032741 vs PDCD1 — BRCA

Explore this scatter interactively →