Positive regulation of interleukin-18 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-18 production pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMK2D, PTPN11, and TONSL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-18 production activity versus CAMK2D in BLOOD_Leukemia (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CAMK2D →	+1.702	+0.174	.003	.002	3	4
CNS	PTPN11 →	-0.805	-0.243	.001	<.001	3	4
OVARY	TONSL →	+1.833	+0.224	<.001	.004	3	3
BLOOD_Leukemia	COX6C →	+0.991	+0.220	<.001	<.001	3	3
BREAST	GPR146 →	+1.525	+0.162	.008	.004	3	3
CNS	EIF2B2 →	-0.941	-0.216	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032741 vs CAMK2D — BLOOD_Leukemia

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