Positive regulation of interleukin-13 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-13 production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ELMO1, HCLS1, and APBB1IP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-13 production activity versus ELMO1 in GBM (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ELMO1 →	+0.339	+0.050	<.001	<.001	3	9
LSCC	HCLS1 →	+0.546	+0.075	<.001	<.001	3	9
GBM	APBB1IP →	+0.388	+0.048	<.001	<.001	3	9
HNSC	ARHGAP25 →	+0.606	+0.066	<.001	<.001	3	9
COAD	SKAP2 →	+0.446	+0.033	.002	<.001	3	8
CCRCC	THEMIS2 →	+0.359	+0.040	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032736 vs ELMO1 — GBM

Explore this scatter interactively →