Positive regulation of interleukin-13 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-13 production pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASGRP2, COX7A2L, and CEACAM4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-13 production activity versus RASGRP2 in LSCC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RASGRP2 →	+0.695	+0.353	.001	.005	3	5
HNSC	COX7A2L →	-0.334	-0.494	<.001	.007	3	3
LSCC	CEACAM4 →	+0.610	+0.349	<.001	.004	2	4
LSCC	DARS2 →	-0.336	-0.284	.007	<.001	3	3
CCRCC	NEMP1 →	-0.246	-0.540	<.001	<.001	3	3
LSCC	NUP37 →	-0.336	-0.252	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032736 vs RASGRP2 — LSCC

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