Positive regulation of interleukin-13 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-13 production pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAS6, SLC26A6, and LYPD6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GAS6 grouped by Positive regulation of interleukin-13 production-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GAS6 →	-2.737	-1.364	.007	<.001	3	4
LIVER	SLC26A6 →	-1.237	-1.257	.004	<.001	3	4
LUNG_NSCLC_LUAD	LYPD6 →	-1.128	-0.674	<.001	.002	3	4
LARGE_INTESTINE	ADRB2 →	-0.462	-1.170	.001	.001	3	4
SOFT_TISSUE	TGFBI →	-3.449	-0.956	.008	.004	3	4
SOFT_TISSUE	TMEM255B →	-1.126	-1.018	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GAS6 by Positive regulation of interleukin-13 production activity — PANCREAS

Explore this box plot interactively →