Positive regulation of interleukin-13 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-13 production pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF170, TTF1, and AGPS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-13 production activity versus RNF170 in BLOOD_Lymphoma (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RNF170 →	+1.385	+1.197	.006	.006	3	4
URINARY_TRACT	TTF1 →	-0.609	-0.530	<.001	.001	3	4
BLOOD_Myeloma	AGPS →	+0.966	+0.402	.008	.007	3	4
OVARY	IL18 →	+2.928	+1.492	<.001	<.001	3	4
BLOOD_Lymphoma	DNASE2 →	+2.293	+1.764	.001	<.001	3	3
BLOOD_Lymphoma	SLC22A18 →	+2.435	+1.383	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032736 vs RNF170 — BLOOD_Lymphoma

Explore this scatter interactively →