Positive regulation of interleukin-12 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-12 production pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ICOS, LPXN, and MS4A6A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-12 production activity versus ICOS in HNSC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ICOS →	+0.904	+0.218	<.001	<.001	3	9
HNSC	LPXN →	+0.719	+0.213	<.001	<.001	3	8
HNSC	MS4A6A →	+0.997	+0.254	<.001	<.001	3	8
LSCC	ARHGAP9 →	+0.809	+0.370	<.001	<.001	3	8
LSCC	ZBP1 →	+0.999	+0.404	<.001	<.001	3	8
GBM	AOAH →	+1.050	+0.236	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032735 vs ICOS — HNSC

Explore this scatter interactively →