Positive regulation of interleukin-12 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-12 production pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD44, CCDC18, and ITGA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD44 grouped by Positive regulation of interleukin-12 production-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CD44 →	-2.297	-0.290	<.001	.004	3	5
OESOPHAGUS	CCDC18 →	+1.078	+0.244	.002	.002	3	4
BLOOD_Myeloma	ITGA3 →	-2.054	-0.585	.004	.006	3	4
STOMACH	C18orf21 →	+0.863	+0.428	.001	.002	3	4
BLOOD_Leukemia	CENPI →	+0.764	+0.164	.005	.003	3	4
BLOOD_Leukemia	HMGB2 →	+0.853	+0.175	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD44 by Positive regulation of interleukin-12 production activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →