Positive regulation of interleukin-10 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-10 production pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4K1, LILRB1, and BTK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-10 production activity versus MAP4K1 in BRCA (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAP4K1 →	+0.836	+0.207	.001	.007	3	8
LSCC	LILRB1 →	+0.669	+0.183	<.001	<.001	3	8
HNSC	BTK →	+0.970	+0.224	<.001	<.001	3	8
LSCC	CXCL13 →	+1.654	+0.289	<.001	<.001	3	8
HNSC	SLAMF6 →	+1.112	+0.168	<.001	<.001	3	8
LSCC	TAGAP →	+0.714	+0.165	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032733 vs MAP4K1 — BRCA

Explore this scatter interactively →