Positive regulation of interleukin-10 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-10 production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LGALS9, SAMHD1, and SASH3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-10 production activity versus LGALS9 in GBM (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LGALS9 →	+0.656	+0.259	<.001	<.001	3	8
GBM	SAMHD1 →	+0.516	+0.314	<.001	<.001	3	7
BRCA	SASH3 →	+0.513	+0.236	<.001	.001	3	7
GBM	SEPTIN1 →	+1.042	+0.281	<.001	<.001	3	7
GBM	SYK →	+0.393	+0.213	<.001	<.001	3	7
BRCA	DOK2 →	+0.684	+0.251	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032733 vs LGALS9 — GBM

Explore this scatter interactively →