Positive regulation of interleukin-10 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-10 production pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BDKRB1, TMEM167A, and ITGA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-10 production activity versus BDKRB1 in BONE (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	BDKRB1 →	-3.066	-0.233	<.001	.002	3	5
BONE	TMEM167A →	-1.590	-0.334	.001	.001	3	5
BONE	ITGA3 →	-5.462	-0.240	<.001	.001	3	5
BONE	MOCOS →	-2.617	-0.314	<.001	.009	3	5
SKIN	TEX264 →	+0.824	+0.224	<.001	.004	3	5
SKIN	ALCAM →	-2.534	-0.228	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032733 vs BDKRB1 — BONE

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