Positive regulation of interleukin-1 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-1 production pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, LILRB1, and PLEK, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-1 production activity versus CSF2RB in TGCT (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	CSF2RB →	+1.816	+0.062	<.001	<.001	3	33
LAML	LILRB1 →	+2.276	+0.121	<.001	<.001	3	33
SKCM	PLEK →	+2.076	+0.051	<.001	<.001	3	33
LAML	LILRB2 →	+3.138	+0.134	<.001	<.001	3	33
LAML	GPR65 →	+1.432	+0.098	<.001	<.001	3	33
SARC	MYO1F →	+1.716	+0.051	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032732 vs CSF2RB — TGCT

Explore this scatter interactively →