Positive regulation of interleukin-1 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-1 production pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB1, PIK3CG, and CD4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-1 production activity versus LILRB1 in GBM (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LILRB1 →	+0.724	+0.159	<.001	<.001	3	9
LSCC	PIK3CG →	+0.693	+0.174	<.001	<.001	3	9
GBM	CD4 →	+0.830	+0.157	<.001	<.001	3	9
GBM	TNFSF8 →	+0.767	+0.171	<.001	<.001	3	9
GBM	IL10RA →	+0.953	+0.156	<.001	<.001	3	9
GBM	BIN2 →	+0.782	+0.185	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032732 vs LILRB1 — GBM

Explore this scatter interactively →