Positive regulation of interleukin-1 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-1 production pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSC22D4, IBA57, and SLC15A4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSC22D4 grouped by Positive regulation of interleukin-1 production-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TSC22D4 →	-0.780	-0.538	<.001	.005	3	4
URINARY_TRACT	IBA57 →	+0.936	+0.362	<.001	<.001	3	3
BREAST	SLC15A4 →	-0.754	-0.850	.002	<.001	3	3
LIVER	NEK10 →	-1.337	-1.414	.009	.003	3	3
BREAST	DTWD2 →	-0.645	-0.759	.005	.007	3	3
BREAST	FOXD4L5 →	-0.132	-0.489	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSC22D4 by Positive regulation of interleukin-1 production activity — LARGE_INTESTINE

Explore this box plot interactively →