Positive regulation of interleukin-1 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-1 production pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF512B, NUDT16L1, and CYB5R1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-1 production activity versus ZNF512B in BREAST (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNF512B →	+1.226	+0.250	<.001	<.001	3	5
BREAST	NUDT16L1 →	+1.297	+0.232	.001	<.001	3	5
OESOPHAGUS	CYB5R1 →	+1.142	+0.271	.003	<.001	3	5
BREAST	ANKRD33B →	-2.004	-0.331	<.001	<.001	3	5
LIVER	STK17A →	-1.783	-0.254	.003	.009	3	4
BREAST	S100A13 →	+1.261	+0.335	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032732 vs ZNF512B — BREAST

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