Positive regulation of interleukin-1 beta production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-1 beta production pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD226, SCIMP, and LCP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-1 beta production activity versus CD226 in UCEC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD226 →	+0.541	+0.185	.007	<.001	3	7
COAD	SCIMP →	+0.485	+0.140	.003	.001	3	7
OV	LCP2 →	+0.994	+0.173	<.001	<.001	3	7
LUAD	SIGLEC10 →	+0.601	+0.131	.002	.002	3	7
LSCC	HRH2 →	+0.659	+0.170	<.001	.001	3	6
BRCA	IL2RA →	+0.869	+0.167	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032731 vs CD226 — UCEC

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