Positive regulation of interleukin-1 beta production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-1 beta production pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZDHHC1, MYEF2, and DTX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZDHHC1 grouped by Positive regulation of interleukin-1 beta production-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZDHHC1 →	-1.028	-0.201	.006	.009	3	3
OESOPHAGUS	MYEF2 →	-3.404	-0.197	<.001	.004	3	3
OESOPHAGUS	DTX1 →	-0.433	-0.177	.001	.004	3	3
BONE	KIF17 →	-1.126	-0.189	<.001	.007	3	3
URINARY_TRACT	CENPJ →	+0.809	+0.434	.004	<.001	3	3
URINARY_TRACT	PKN3 →	+2.250	+0.338	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZDHHC1 by Positive regulation of interleukin-1 beta production activity — OESOPHAGUS

Explore this box plot interactively →