Positive regulation of interleukin-1 beta production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-1 beta production pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLIS2, P3H4, and STK17A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-1 beta production activity versus GLIS2 in BLOOD_Myeloma (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GLIS2 →	+1.850	+0.188	.001	.007	2	5
KIDNEY	P3H4 →	+1.395	+0.195	.002	.007	3	4
LIVER	STK17A →	-1.911	-0.275	.001	.009	3	4
LIVER	SIRT4 →	+0.877	+0.287	<.001	.005	3	4
BREAST	PRSS16 →	-2.030	-0.214	.002	.004	3	4
BREAST	CISH →	+1.859	+0.206	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032731 vs GLIS2 — BLOOD_Myeloma

Explore this scatter interactively →