Positive regulation of interleukin-1 alpha production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-1 alpha production pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MS4A6A, SELPLG, and FAM78A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-1 alpha production activity versus MS4A6A in UCEC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MS4A6A →	+1.119	+0.852	<.001	<.001	3	9
GBM	SELPLG →	+0.850	+0.240	<.001	<.001	3	9
UCEC	FAM78A →	+0.905	+0.945	<.001	<.001	3	9
LUAD	TNFSF8 →	+0.756	+0.731	<.001	<.001	3	9
UCEC	NCKAP1L →	+1.037	+0.936	<.001	<.001	3	9
GBM	LST1 →	+0.628	+0.224	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032730 vs MS4A6A — UCEC

Explore this scatter interactively →