Positive regulation of interleukin-1 alpha production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-1 alpha production pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGFG2, C1orf198, and LARP1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGFG2 grouped by Positive regulation of interleukin-1 alpha production-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AGFG2 →	+0.603	+1.029	.009	.001	3	5
PANCREAS	C1orf198 →	+0.861	+1.466	.001	.003	3	4
BLOOD_Myeloma	LARP1B →	+0.818	+1.702	.005	.001	3	4
SKIN	FBXO7 →	+1.069	+1.417	.002	.002	3	4
BREAST	EGF →	+1.679	+0.990	<.001	<.001	3	4
SKIN	IRX3 →	-0.937	-0.941	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGFG2 by Positive regulation of interleukin-1 alpha production activity — SKIN

Explore this box plot interactively →