Positive regulation of interleukin-1 alpha production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-1 alpha production pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF426, KPNA5, and ACMSD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF426 grouped by Positive regulation of interleukin-1 alpha production-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZNF426 →	-0.238	-0.284	.005	<.001	3	4
OVARY	KPNA5 →	-0.138	-0.299	.003	<.001	3	4
BREAST	ACMSD →	-0.168	-0.237	.005	.002	3	3
BREAST	ALDH4A1 →	+0.161	+0.218	<.001	<.001	3	3
BLOOD_Myeloma	TRIM72 →	-0.705	-0.285	.001	.009	2	4
OESOPHAGUS	GSDME →	+0.177	+0.324	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF426 by Positive regulation of interleukin-1 alpha production activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →