Positive regulation of type II interferon production

Across TCGA patient cohorts, RNA activity of the Positive regulation of type II interferon production pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AIM2, IL21R, and LILRB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of type II interferon production activity versus AIM2 in CCRCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	AIM2 →	+0.991	+1.123	<.001	<.001	3	7
LSCC	IL21R →	+0.714	+0.535	<.001	<.001	3	6
LSCC	LILRB1 →	+0.685	+0.677	<.001	<.001	3	6
HNSC	ARHGAP9 →	+0.738	+0.490	<.001	<.001	3	6
HNSC	LILRB2 →	+0.654	+0.491	.002	<.001	3	6
CCRCC	CD72 →	+0.767	+1.031	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032729 vs AIM2 — CCRCC

Explore this scatter interactively →