Positive regulation of type II interferon production

Across TCGA cell cohorts, RNA activity of the Positive regulation of type II interferon production pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB8, FTO, and EDF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSMB8 grouped by Positive regulation of type II interferon production-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PSMB8 →	+1.561	+0.289	.007	.005	3	5
BREAST	FTO →	+0.600	+0.094	.009	.009	3	5
UPPER_AERODIGESTIVE_TRACT	EDF1 →	+0.803	+0.378	<.001	.008	3	5
LUNG_NSCLC_LUSC	LOXL4 →	+1.891	+0.119	.003	.004	3	4
BLOOD_Lymphoma	RASA2 →	+1.005	+0.362	.002	.008	3	4
LIVER	TMEM102 →	+0.804	+0.396	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSMB8 by Positive regulation of type II interferon production activity — BLOOD_Lymphoma

Explore this box plot interactively →