Positive regulation of type II interferon production

Across TCGA cell cohorts, RNA activity of the Positive regulation of type II interferon production pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGL1, SAP130, and INO80E, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of type II interferon production activity versus RGL1 in KIDNEY (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RGL1 →	+1.560	+0.174	<.001	.003	3	6
SKIN	SAP130 →	+0.489	+0.343	.001	.007	3	6
BLOOD_Leukemia	INO80E →	+0.375	+0.186	.008	.006	3	6
PANCREAS	HS1BP3 →	+1.106	+0.298	<.001	.001	3	5
OVARY	UCK2 →	+0.916	+0.326	.003	.003	3	5
PANCREAS	WDR76 →	+0.707	+0.258	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032729 vs RGL1 — KIDNEY

Explore this scatter interactively →