Positive regulation of interferon-beta production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interferon-beta production pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF3L, PSME2P2, and RPL34, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interferon-beta production activity versus EIF3L in LSCC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EIF3L →	-0.423	-0.220	.001	<.001	3	6
LSCC	PSME2P2 →	+0.473	+0.183	<.001	.001	3	6
CCRCC	RPL34 →	-0.411	-0.155	<.001	.002	3	6
LSCC	ZDHHC4P1 →	+0.886	+0.307	<.001	<.001	3	5
BRCA	RPL22 →	-0.453	-0.165	.002	.003	3	5
LSCC	EPSTI1 →	+1.029	+0.302	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032728 vs EIF3L — LSCC

Explore this scatter interactively →