Positive regulation of interferon-beta production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interferon-beta production pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNMA1, DNAH5, and SLC39A13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNMA1 grouped by Positive regulation of interferon-beta production-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	KCNMA1 →	-4.593	-1.614	.003	<.001	3	5
LIVER	DNAH5 →	-0.763	-1.366	.008	.007	3	5
LIVER	SLC39A13 →	-1.295	-1.436	<.001	<.001	3	4
BREAST	RAB33B →	+0.532	+0.809	<.001	.004	3	4
STOMACH	NR3C1 →	-2.761	-1.061	<.001	.007	3	4
LIVER	ZNF620 →	+0.809	+1.662	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNMA1 by Positive regulation of interferon-beta production activity — LIVER

Explore this box plot interactively →