Positive regulation of interferon-beta production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interferon-beta production pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NVL, GTF2H4, and PLA2G4A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interferon-beta production activity versus NVL in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NVL →	+0.472	+0.176	.006	<.001	3	5
LARGE_INTESTINE	GTF2H4 →	+0.781	+0.185	.002	<.001	3	5
PANCREAS	PLA2G4A →	-1.208	-0.188	.003	.004	3	4
PANCREAS	AK6 →	+0.634	+0.197	.003	.002	3	4
PANCREAS	SEPHS1 →	+0.781	+0.207	.001	.007	3	4
PANCREAS	CFH →	-1.904	-0.191	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032728 vs NVL — LUNG_NSCLC_LUAD

Explore this scatter interactively →