Positive regulation of interferon-alpha production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interferon-alpha production pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLPP7, HDAC5, and P3H3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interferon-alpha production activity versus PLPP7 in BRCA (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLPP7 →	-0.392	-0.532	<.001	.002	3	6
BRCA	HDAC5 →	-0.487	-0.698	.006	<.001	3	5
BRCA	P3H3 →	-0.764	-0.491	<.001	<.001	3	5
CCRCC	FGF1 →	-0.736	-0.753	.001	.001	3	5
GBM	DACT3 →	-0.539	-0.405	.002	.008	3	5
LSCC	KCTD15 →	-0.686	-0.235	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032727 vs PLPP7 — BRCA

Explore this scatter interactively →