Positive regulation of interferon-alpha production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interferon-alpha production pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL27RA, TRAF3IP2, and RPL34, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IL27RA grouped by Positive regulation of interferon-alpha production-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	IL27RA →	+1.191	+0.387	.001	<.001	3	6
LUNG_SCLC	TRAF3IP2 →	-2.683	-0.240	<.001	.004	3	5
STOMACH	RPL34 →	+0.763	+0.276	.009	.007	3	3
STOMACH	BTBD1 →	+0.577	+0.224	<.001	.005	3	3
SOFT_TISSUE	CCDC9B →	-3.477	-0.308	.004	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	PCGF5 →	+1.095	+0.278	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IL27RA by Positive regulation of interferon-alpha production activity — LIVER

Explore this box plot interactively →