Positive regulation of interferon-alpha production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interferon-alpha production pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAT1, RIPK2, and IFIT1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interferon-alpha production activity versus STAT1 in BLOOD_Lymphoma (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	STAT1 →	+2.454	+0.134	<.001	<.001	3	13
BLOOD_Leukemia	RIPK2 →	+1.118	+0.100	.005	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	IFIT1 →	+3.243	+0.117	<.001	<.001	3	11
LUNG_NSCLC_LUSC	ZC3HAV1 →	+1.025	+0.101	.008	.006	3	11
KIDNEY	IFI44L →	+3.039	+0.105	.004	.002	3	10
KIDNEY	ISG15 →	+2.120	+0.104	.004	.002	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032727 vs STAT1 — BLOOD_Lymphoma

Explore this scatter interactively →