Positive regulation of granulocyte macrophage colony-stimulating factor production

Across TCGA patient cohorts, RNA activity of the Positive regulation of granulocyte macrophage colony-stimulating factor production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGB2, THEMIS2, and ZNF219_S114, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of granulocyte macrophage colony-stimulating factor production activity versus ITGB2 in GBM (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ITGB2 →	+0.663	+0.084	<.001	<.001	3	9
BRCA	THEMIS2 →	+0.538	+0.054	<.001	<.001	3	8
LSCC	ZNF219_S114 →	-0.818	-0.070	<.001	<.001	3	8
BRCA	CYBB →	+0.856	+0.043	<.001	<.001	3	8
GBM	HCK →	+0.649	+0.076	<.001	<.001	3	8
BRCA	HK3 →	+0.706	+0.046	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032725 vs ITGB2 — GBM

Explore this scatter interactively →