Positive regulation of granulocyte macrophage colony-stimulating factor production

Across TCGA patient cohorts, RNA activity of the Positive regulation of granulocyte macrophage colony-stimulating factor production pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFATC4, MECR, and IFT122, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of granulocyte macrophage colony-stimulating factor production activity versus NFATC4 in UCEC (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NFATC4 →	-0.738	-0.822	<.001	<.001	3	3
UCEC	MECR →	-0.442	-0.780	<.001	.001	3	3
UCEC	IFT122 →	-0.680	-0.776	<.001	.006	3	3
OV	HDAC11 →	-0.672	-0.519	.001	.008	2	4
BRCA	DPCD →	-0.662	-0.551	<.001	<.001	3	3
BRCA	HNRNPCP6 →	-0.690	-0.354	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032725 vs NFATC4 — UCEC

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