Positive regulation of granulocyte macrophage colony-stimulating factor production

Across TCGA cell cohorts, RNA activity of the Positive regulation of granulocyte macrophage colony-stimulating factor production pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSCAN23, CENPN, and ZNF746, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZSCAN23 grouped by Positive regulation of granulocyte macrophage colony-stimulating factor production-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZSCAN23 →	-0.420	-0.526	.006	.008	3	4
LUNG_NSCLC_LUAD	CENPN →	+0.822	+0.620	<.001	.003	3	3
LUNG_NSCLC_LUAD	ZNF746 →	-0.601	-0.552	.001	.002	3	3
BLOOD_Lymphoma	KIFC2 →	-0.667	-1.901	.006	<.001	2	4
STOMACH	RAB5B →	-0.504	-0.818	.003	.005	3	3
STOMACH	THEMIS2 →	-1.065	-0.863	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZSCAN23 by Positive regulation of granulocyte macrophage colony-stimulating factor production activity — CNS

Explore this box plot interactively →