Positive regulation of chemokine production

Across TCGA cell cohorts, RNA activity of the Positive regulation of chemokine production pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMIGO2, PYCARD, and TSPAN13, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chemokine production activity versus AMIGO2 in BONE (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	AMIGO2 →	-4.995	-0.489	<.001	.007	3	7
OESOPHAGUS	PYCARD →	-3.361	-0.279	.004	.005	3	7
URINARY_TRACT	TSPAN13 →	-2.924	-0.494	.005	<.001	3	6
PANCREAS	GTF2H2C →	+0.846	+0.258	<.001	.003	3	6
URINARY_TRACT	DAPP1 →	-3.320	-0.381	<.001	<.001	3	6
LUNG_SCLC	CANT1 →	-0.757	-0.222	.004	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032722 vs AMIGO2 — BONE

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