Positive regulation of chemokine production

Across TCGA cell cohorts, RNA activity of the Positive regulation of chemokine production pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCNP, DDX3X, and TBCA, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chemokine production activity versus PCNP in LUNG_NSCLC_LUSC (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PCNP →	+1.867	+0.420	<.001	<.001	3	16
URINARY_TRACT	DDX3X →	+1.571	+0.452	<.001	<.001	3	15
LUNG_NSCLC_LUSC	TBCA →	+2.697	+0.341	.002	.002	3	14
URINARY_TRACT	RPS17 →	+1.148	+0.401	.005	.004	3	14
URINARY_TRACT	EIF3I →	+1.782	+0.344	.001	.001	3	14
URINARY_TRACT	NUDC →	+1.814	+0.344	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032722 vs PCNP — LUNG_NSCLC_LUSC

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