Negative regulation of interleukin-8 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-8 production pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, IL1RN, and CLEC2B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-8 production activity versus ANXA1 in HNSC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ANXA1 →	+1.364	+0.154	<.001	<.001	3	6
HNSC	IL1RN →	+1.200	+0.236	<.001	<.001	3	5
GBM	CLEC2B →	+0.695	+0.226	<.001	.001	3	5
OV	BCL2A1 →	+0.705	+0.196	.002	.005	3	5
LSCC	BTBD8 →	-0.507	-0.209	.001	.001	2	5
HNSC	AKT3 →	-0.413	-0.123	.009	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032717 vs ANXA1 — HNSC

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