Negative regulation of interleukin-8 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-8 production pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, ANXA4, and POLD4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-8 production activity versus ANXA1 in LUNG_SCLC (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ANXA1 →	+4.257	+1.561	<.001	<.001	3	7
OVARY	ANXA4 →	+2.812	+0.407	<.001	<.001	3	7
LUNG_SCLC	POLD4 →	+1.675	+1.522	.002	.001	2	6
STOMACH	ABCC3 →	+4.324	+0.294	<.001	<.001	3	5
STOMACH	IL18 →	+3.055	+0.229	.001	.004	2	6
STOMACH	INAVA →	+3.269	+0.313	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032717 vs ANXA1 — LUNG_SCLC

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