Negative regulation of interleukin-5 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-5 production pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2A1, SIGLEC10, and PRF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-5 production activity versus BCL2A1 in GBM (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BCL2A1 →	+1.496	+0.733	<.001	<.001	3	6
GBM	SIGLEC10 →	+1.578	+0.658	<.001	<.001	3	5
GBM	PRF1 →	+0.947	+0.579	<.001	<.001	3	5
GBM	TYMP →	+0.881	+0.533	<.001	<.001	3	5
GBM	GZMA →	+1.221	+0.553	<.001	.001	3	5
BRCA	CSK →	+0.404	+0.224	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032714 vs BCL2A1 — GBM

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