Negative regulation of interleukin-4 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-4 production pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LEF1, NRP2, and EFEMP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-4 production activity versus LEF1 in UCEC (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LEF1 →	+1.082	+0.101	<.001	<.001	3	7
GBM	NRP2 →	+0.457	+0.082	.003	.003	3	6
GBM	EFEMP1 →	+0.568	+0.086	.001	.005	3	6
LUAD	UTRN →	+0.238	+0.077	<.001	<.001	3	6
PDAC	FBLN1 →	+0.639	+0.079	<.001	<.001	3	6
PDAC	ISLR →	+0.606	+0.068	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032713 vs LEF1 — UCEC

Explore this scatter interactively →