Negative regulation of interleukin-4 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-4 production pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPD2, KNL1, and ZNF724, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-4 production activity versus NCAPD2 in CCRCC (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NCAPD2 →	+0.694	+0.676	<.001	.001	3	4
CCRCC	KNL1 →	+0.761	+0.507	.005	.009	3	4
CCRCC	ZNF724 →	+0.770	+0.658	<.001	.001	3	4
COAD	TRNP1 →	+1.231	+0.202	.007	.006	2	5
CCRCC	F11 →	-0.802	-0.477	.004	.004	3	4
BRCA	PRIM1 →	+0.430	+0.280	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032713 vs NCAPD2 — CCRCC

Explore this scatter interactively →