Negative regulation of interleukin-4 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-4 production pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDM2, C18orf21, and GDPD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MDM2 grouped by Negative regulation of interleukin-4 production-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MDM2 →	+0.948	+1.059	.002	.001	3	5
LUNG_NSCLC_LUAD	C18orf21 →	+0.737	+0.865	.004	.007	3	5
STOMACH	GDPD1 →	+1.532	+1.706	.002	<.001	3	4
PANCREAS	MAP3K14 →	-1.242	-1.165	.005	.004	3	4
LUNG_SCLC	ERLIN2 →	+0.835	+1.125	.005	.001	3	4
URINARY_TRACT	PCSK6 →	+4.297	+1.886	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MDM2 by Negative regulation of interleukin-4 production activity — BREAST

Explore this box plot interactively →