Negative regulation of interleukin-18 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-18 production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPN, LCP2, and NCF2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-18 production activity versus SPN in GBM (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPN →	+0.554	+0.092	<.001	<.001	3	9
OV	LCP2 →	+0.450	+0.119	<.001	.005	3	8
GBM	NCF2 →	+0.532	+0.086	<.001	<.001	3	8
GBM	SAMSN1 →	+0.550	+0.105	<.001	<.001	3	7
GBM	DEF6 →	+0.463	+0.100	<.001	<.001	3	7
LUAD	DOCK8 →	+0.422	+0.076	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032701 vs SPN — GBM

Explore this scatter interactively →