Negative regulation of interleukin-18 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-18 production pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR8, CLEC4A, and SRGN, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-18 production activity versus TLR8 in OV (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TLR8 →	+0.888	+0.170	.005	.006	3	2
OV	CLEC4A →	+0.538	+0.302	<.001	.001	3	2
OV	SRGN →	+1.554	+0.258	.001	.004	3	2
OV	SSR1 →	+0.477	+0.175	.002	.005	3	2
OV	HAVCR2 →	+0.757	+0.175	.003	.005	3	2
OV	GPNMB →	+1.204	+0.210	.008	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032701 vs TLR8 — OV

Explore this scatter interactively →